The association of the expression level of anti-apoptosis protein p-AKT and gastric mucosal injury induced by indomethacin in mice / 中华风湿病学杂志
Chinese Journal of Rheumatology
; (12): 560-562,插三, 2008.
Article
in Zh
| WPRIM
| ID: wpr-554387
Responsible library:
WPRO
ABSTRACT
Objective To investigate the association of the expression level of anti-apoptosis protein p-AKT and gastric mucasal injury induced by indomethacin in mice.Methods The cytotoxicity induced by indomethacin was measured by LDH assay.The p-AKT expression levels were measured in the gastric mucosal tissues from C57BL/6 mice and rat gastric mucosal (RGM-1) cell lines treated with indomethacin lay western blotting.Results The cytotoxicity induced by indomethacin was in a dose dependent manner.Compared with the control,a typical histological appearance of gastric ulcer was observed in the gastric mucosa of in domethacin-administered mice;p-AKT protein expression in the gastric mucosa of mice and RGM-1 cell lines was decreased after treated with indomethacin.Conclusion The reduction of Anfi-apoptesis protein p-AKT expression may be a new mechanism for the gastric mucosal injury induced by indomethacin.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Rheumatology
Year:
2008
Type:
Article