Clinical study on effects of tongxinluo and Nitroglycerin in patients with conge stive heart failure / 中国临床药理学与治疗学

ABSTRACT

AIM: To investigate the clinical effects of tongxinluo an d nitroglycerin in patients with congestive heart failure(CHF).METHODS: 112 CHF patients were assigned to the treatment group (60 cases) and the control group (52 cases) randomly.The patients in the control group were treat ed with nitroglycerin and routine general therapy, and those in the treatment gr oup were administrated with tongxinluo 3 capsules after each of three meals besi des nitroglycerin and routine general therapy. The echocardiography, hemorheolo gy and clinical examination were performed in patients with CHF prior and after 2-week treatment. The cardiac function and alternation of the hemorheology were observed after treatment. RESULTS: The total effective rate in the treatment group was higher than that in the control group. The cardiac func tion in the treatment group changed significantly,and the levels of plasma visc osity decreased in both groups significantly after treatment, especially in trea tment group. CONCLUSION: Tongxinluo can improve the cardiac fu nction and blood coagulation in patients with CHF.