Effects of hypertonic sodium chloride hydroxyethyl starch on blood flow of intestinal mucosal microcirculation in rats with hemorrhagic shock / 解放军医学杂志

ABSTRACT

Objective To study the effects of hypertonic sodium chloride hydroxyethyl starch(HSH), blood flow of microcirculation (IMMBF) in Sprague-Dawley(SD) rats. Methods Sixty healthy SD rats were included in the study, 6 of which were used as normal control and their IMMBF was regarded as the baseline. Fifty-four rats were subjected to hemorrhagic shock with BP of 40mmHg for 60min, Among these 54 rats, IMMBF was measured in 6, without resuscitation. In 24 shock rats, HSH was given in a dose of 6ml/kg as the HSH group, and in 24 shock rats lactated Ringer solution (RL) was given in a volume twice of volume of blood loss as the RL group. At 90, 120, 180 and 300 minutes after shock, their IMMBF was measured, and specimens of their intestinal wall were harvested for pathological examination. Results The results showed that IMMBF baseline level of SD rats was 110.67?11.63mV. It was decreased to 25.78?10.77mV after shock for 60 minutes. The IMMBF in HSH group was 103.22?7.96, 92.50?14.47, 86.17?10.35 and 122.33?8.30mV at the 4 time points, respectively, the IMMBF in RL group was 61.89?6.41, 64.95?12.94, 63.42?6.46 and 86.50?13.51mV, respectively the difference between the two groups at every time point was significant with P value