Changes of NO concentrations of different tissues and blood pressure in stress rats / 中国临床药理学与治疗学

ABSTRACT

AIM: To study the changes of NO concentrations of different ti ssues in stress rats. METHODS: Add stimulation with experiments employed electric food-shock and noise of busser as stressor for 15 days in SD rats,NO concentrations and BP were measured. RESULTS: In stress group, BPs increased before and after stress stimulation,but decreased levels NO concentrations of plasma, and there was no detectable amounts of NO in auricl e, ventricle, vessel and adrenal. In stress +L-arg group, BPs d id not increase before and after stress stimulation, NO concentrations of plasma increased, but auricle, ventricle, vessel and adrenal maintained the concentrat ions of NO. CONCLUSION: The stress stimulation can increase BP a nd low NO concentration, and L-arg can resist the response.