The study of drug eluting biodegradable intravascular stent with antiproliferation agent-paclitaxel in preventing vascular restenosis / 中华放射学杂志

ABSTRACT

Objective To define the effect of drug eluting BIS with antiproliferation agent-paclitaxel in preventing vascular restenosis.Methods Bare BIS and drug BIS with 60 ?g paclitaxel were prepared. Both types of the BIS were implanted into the infrarenal restenosis aortas in canine models, and the animals were euthanized 6 weeks after implantation for histopathological, morphometric and immunohistochemical assessment.Results The mean lumen area of bare BIS group was (77 586.5?66.0) ?m2, and lumen of paclitaxel eluting BIS group was (113 435.9?71.0) ?m2. The mean neointima area of bare BIS group was (24 803?56) ?m2, and paclitaxel eluting BIS group was (12 931?63) ?m2. The PCNA-positive ratio was (38?15)% in bare BIS group and (11?0.31)% in paclitaxel eluting BIS group. The statistically significant difference between the two groups were noted ( P