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Association of dopamine ?-hydroxylase polymorphism with attention deficit hyperactivity disorder in children / 北京大学学报(医学版)
Journal of Peking University(Health Sciences) ; (6)2004.
Article in Chinese | WPRIM | ID: wpr-555079
ABSTRACT

Objective:

To study the association of dopamine ?-hydroxylase gene 5′ flanking region polymorphism -1021 C→T with attention deficit hyperactivity disorder (ADHD) in Han children.

Methods:

ADHD was diagnosed according to the DSM-Ⅳ criteria . DNA was extracted and PCR was performed to examine the DBH-1021C→T polymorphism. HHRR was used to test the association of dopamine ?-hydroxylase gene with different subtypes of ADHD.

Results:

HHRR results showed this polymorphism had a tendency to be associated with the inattention subtype (P=0.067) and the combined subtype (P=0.076). The T allele was the protective factor of the inattentive subtype (P= 0.07), and the risk factor of the combined subtype (P=0.08). After dividing the 292 nuclear families according to sex, DBH-1021C→T polymorphism was found to be associated with the combined subtype (P=0.04) with the T allele as the risk factor (P=0.02). There were no positive findings among the girl nuclear families of ADHD.

Conclusion:

DBH gene is related to ADHD combined subtype and inattention subtype. The genetic basis of ADHD combined subtype and is inattention is different, and is influenced by sex factor.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Risk factors Language: Chinese Journal: Journal of Peking University(Health Sciences) Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Risk factors Language: Chinese Journal: Journal of Peking University(Health Sciences) Year: 2004 Type: Article