Clinical and electromyography analysis of 46 cases of adult spinal muscular atrophy / 中国实用内科杂志

ABSTRACT

Objective To summarize the clinical, electromyography and muscular pathological feature in adult spinalmuscular atrophy (SMA_4). Methods The clinical and electromyography and pathological materials from 48 patients withSMA_4. were studied in retrospect tively. Results SMA_4 onset was averaged 38.23 years old,The disease showed proximalweakness and atrophy. The electromyoguphy in the patients with SMA_4. presented as abnormal insertion potential,fibrilla-tion potential and fascicular potential, positive spike in some patients, remarkable increase of mean amplitude, mean timelimit and polyphasic action potential,and so on. Muscle biopsy showed 1. small groups atrophy mainly;2. extensive fibertype grouping and more hypertrophic fiber. Conclusions SMA_4 could be diagnosed by the clinical manifestations andelectromyography and muscle biopsy.