New light on nomegestrol acetate pharmacological profile / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-555735
ABSTRACT
Nomegestrol acetate, 19-norprogesterone de ri vatives, has been used for oral contraception. Recently, studies showed that nom egestrol was a selective estrogen enzyme modulator (SEEM). Nomegestrol is capabl e of inhibiting estrone sulfatase and 17-beta-hydroxysteroid dehydrogenase (17 beta-HSD) and increasing the activity of sulfotransferase,which will provide a new option in the treatment of breast cancer. In addition, nomegestrol has stro ng reversal effects on multidrug resistance in breast cancer cells. In vitro, nomegestrol also exhibits as an inhibitor on endometrial proliferation in uter us. These advances will be introduced in the present review.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
2003
Type:
Article
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