Association between luteinizing hormone ?-subunit gene Gly102Ser polymorphism and polycystic ovary syndrome and premature ovarian failure / 第二军医大学学报

ABSTRACT

Objective:To study the relationship between luteinizing hormone(LH) ?-subunit gene Gly102Ser polymorphism and polycystic ovary syndrome and premature ovarian failure. Methods: The LH? gene Gly102Ser polymorphism was analyzed in polycystic ovary syndrome(70 cases),premature ovarian failure(34 cases) and normal group(90 cases) by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). Results: The LH? gene allelic frequencies of A,G were 0.100, 0.900;0.079,0.921;0.017,0.983 in PCOS,POF and control groups, respectively. The A allele frequencies of LH? gene in PCOS and POF were higher than those in control groups(? 2=10.872,4.413,P0.05). Conclusion: The LH? gene Gly102Ser polymorphism exists in both PCOS and POF people,which is associated with PCOS but not related to POF,and might be a risk factor for PCOS.