Influence of recombinant growth hormone on protein metabolismin hepatocirrhosis: an animal experiment / 肠外与肠内营养
Parenteral & Enteral Nutrition
;
(6)2004.
Article
in Chinese
| WPRIM
| ID: wpr-555823
ABSTRACT
Objective:
We observed the influence of recombinant human growth hormone(rhGH) on protein metabolism in hepatocirrhotic rats and investigated mechanisms.Methods:
Ninety rats were randomized into three groups(n=30 for each group) group A(normal rats), B(cirrhotic rats) and C(cirrhotic rats receiving rhGH). Rats in group C were subcutaneously given rhGH with a dosage of 1 U/(kg?d) for up to 1 week. The plasma concentrations of albumin(ALB), prealbumin(PA), transferrin(TF) and insulin-like growth factor-1(IGF-1) were detected on experimental day 14. And liver biopsy was taken to examine the expression level of albumin mRNA with TR-PCR.Results:
The albumin, prealbumin, transferrin and IGF-1 levels in groups A and C were significantly higher than those in group B. The expression level of albumin mRNA in grup C was significantly higher than that in group B.Conclusions:
The rhGH can improve the level of IGF-1 in plasma and improve the expression of albumin mRNA. Moreover, it may significantly improve the synthesis of protein and attenuate hypoproteinemia in cirrhotic rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Parenteral & Enteral Nutrition
Year:
2004
Type:
Article
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