Influence of schisandrone on levels of IL-1? and iNOS mRNA in hippocampus of rats with Alzheimer-like disease / 第二军医大学学报

ABSTRACT

Objective:To observe the influence of schisandrone on the levels of IL-1? and iNOS mRNA in the hippocampus of rats with Alzheimer-like disease(AD) and to investigate the probable prevention and therapy effect of schisandrone on AD. Methods: Totally 30 male SD rats, 8-12 weeks old, weighing 250-300 g, were randomly divided into 3 groups blank control group,AD model group and schisandrone intervention group(n=10). The animal model of AD was established by 10 mmol/L amyloid-beta protein(A? 25-35 ) 5 ?l stereotactic injection into lateral cerebral ventricle of rats and the rats of schisandrone intervention group were administrated with corn oil with 1 mmol/L schisandrone. And then the levels of IL-1? and iNOS mRNA in the hippocampus were detected by RT-PCR. Results: The levels of IL-1? and iNOS mRNA in the hippocampus of rats with Alzheimer-like disease (0.333 7?0.122 3, 0.266 6?0.088 5) decreased obviously after administration of schisandrone (0.969 3?0.153 9, 0.666 0?0.121 1)(P