Alterations of ion channels in cerebrovascular smooth muscle cells during hypert ension / 中国药理学通报

ABSTRACT

Cerebrovascular remodeling is the most important pathologic change during hypertension. Stroke induced by hypertension is threatening thousands of people's lives. The ion channels in cerebrovascular smooth muscle cells may be altered during hypertension and thus the abnormality of cytosolic ion concentration can accelerate cerebrovascular remodeling. These channels, including potassium channels, calcium channels and chloride channels, may play an important role in the cerebrovascular remodeling during hypertension.