Anti-inflammatory and antibacterial effects of total flavones of oldenlandia diffusa willd / 中国药理学通报

ABSTRACT

Aim To study anti-inflammatory and antibacterial effects of total flavones of oldenlandia diffusa Willd(FOD).Methods The models of dimethylbenzene-induced ear swollen in mice,turpentine-induced granuloma pouch in rats,paw edema caused by egg white in rats,increased vascular permeability by acetic acid in mice and the antibacterial activity in vitro were used to study FOD. Results FOD(15、30 and 60 mg?kg~-1 )show a marked suppressive effect on dimethylbenzene-induced ear swollen and increased vascular permeability in mice. In addition,FOD(12、24 and 48 mg?kg~-1 ) could reduce the paws edema and the granuloma pouch in rats.On the other hand,FOD had significally bacteriostatic effects against eight kinds of bacterial in vitro, in which effect on coccus is superior to that on bacillus.Conclusion FOD has anti-inflammatory and antibacterial effects.