Relationship between Herpes simplex virus infection and acute myocardial infarction / 中国实用内科杂志

ABSTRACT

ObjectiveTo investigate the correlations between Herpes simplex virus (HSV) infection and acute myocardial infarction(AMI).MethodsSpecific antibodies and DNA to HSV-1 were measured in 51 patients with AMI(AMI group),42 patients with old myocardial infarction (OMI group) and 31 normal controls (NC group) who had no angiographic evidence of coronary artery disease.Moreover,the changes of and relationships between fibrinogen(Fg),6-Keto-prostaglandin-F 1? (6-Keto-PGF 1? ),Thromboxane B 2 (TXB 2 ),P-selection(GMP 140 ) and HSV-1 infection were determined in the three groups.ResultsThe prevalence of HSV-1IgG antibody was associated with AMI(OR4.266).Adjustment for the major cardiovascular risk factors didn't attenuate this correlation(OR3.321).Those who were HSV-1 positive in the AMI group had significantly higher levels of Fg,TXB 2 and GMP 140 and a significantly lower level of 6-Keto-PGF 1? than those who were HSV-1 negative in the same group.Correlation analysis revealed that the average concentration of IgG antibody to HSV-1 was positively associated with the levels of Fg,TXB 2 and GMP 140 but negatively associated with the level of 6-Keto-PGF 1? in the HSV-1 positive patients of the AMI group.ConclusionThere is a significant correlation between HSV-1 infection and AMI.HSV-1 infection is associated with Fg,TXB 2 ,6-Keto-PGF 1? and GMP 140 .