The effect of bisoprolol on action potential duration (APD) and K~+ current in ventricular myocytes after myocardial infarction / 解放军医学杂志
Medical Journal of Chinese People's Liberation Army
;
(12)1983.
Article
in Chinese
| WPRIM
| ID: wpr-556502
ABSTRACT
Objective To investigate the changes of action potential duration (APD) and transient outward K + current (I to) and inward rectifier K + current(I K1) of ventricular myocytes after 3 weeks of myocardial infarction, and to inquire into the effect of bisoprolol. Methods APD was recorded with microelectrode. Ventricular myocytes were singly isolated from rabbit heart using modified Langendoff perfusion and soaked with collagenase. I to and I K1 of single rabbit ventricular myocytes were recorded by whole-cell path-clamp technique. Results Both APD 50 and APD 90 of the cell from noninfarcted region in MI group were markedly longer than that in sham group (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Medical Journal of Chinese People's Liberation Army
Year:
1983
Type:
Article
Similar
MEDLINE
...
LILACS
LIS