Study on Dosage Application of Herbs in Class Formulas of KaixinSan and Their Actions on Depression / 中华中医药杂志

ABSTRACT

Objective: To study the dosage application of herbs in class formulas of KaixinSan recorded in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy (Taiping Huimin Hejiju Fang), Essential Recipes for Emergent Use Worth A Thousand Gold (Beiji Qianjin Yao Fang) and Records of Approved Cases of Ancient and Recent Times (Gujin Luyan) and their actions on depression. Method: According to the dosage proportion of different herbs in the three formulas in the three books, two methods were adopted in terms of decocting different herbs separately and mixing them thereafter(group of decocting separately) as well as extracting after decocted all the herbs together (group of decocting together). Classical anti-depression mice models--forced swimming and tail suspending experiments were observed. The data of immovability time of mice were analyzed by statistics. Result: All the class formulas of KaixinSan which have the same medication but different proportion in the three medical books can reduce the immovability time of mice in forced swimming and tail suspending experiments. But the action of KaixinSan recorded in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy was prominent, and the action of the group of decocting together was superior to that of separated decocting. There was significant difference between the group of decocting together in low dosage and the controlled one (P