Analysis on the drug tolerance of Acinetobacter baumanni and Stenotrophomonas maltophilia / 解放军医学杂志

ABSTRACT

Objective To investigate the drug tolerance of Acinetobacter baumanni and Stenotrophomonas maltophilia . Methods The antimicrobial susceptibility tests for 275 isolates of Acinetobacter baumanni and 107 isolates of Stenotrophomonas maltophilia from 2000 to 2004 were measured by MicroScan WarkAway 96 The chemotherapeutic effects of 18 cases of sequent infection with Acinetobacter baumanni and Stenotrophomonas maltophilia was analyzed. Results The resistance of the two species of bacteria to twelve antibiotics increased obviously during the last five years, especially from 2000 to 2001. The resistant rate of Acinetobacter baumanni to Cefepime、Cefotaxime、Ceftazidime and Ceftriaxonewas was 20~50% in 2000, but raised to 70%~81% in 2004. For Acinetobacter baumanni to Amikacin、Amp/sulbac、Ciprofloxacin、Gentamicin、Tobramycin and Trimeth/Sulfa, the resistant rate was 20%~40% in 2000, while 63~86% in 2004. The lowest resistant rate was to Imipenem, only 7% or so. The resistant rate of Stenotrophomonas maltophilia to Ciprofloxacin、Ceftazidime、ceftriaxone and Tobramycin was 25%、50%、0% and 0%, respectively, in 2000, but in 2004 year, was 76%、76%、95% and 95%, respectively. Stenotrophomonas maltophilia showed a high drug tolerance to other antibiotics. Conclusion To strengthen the monitoring of the antibiotic resistance of Acinetobacter baumanni and Stenotrophomonas maltophilia and the monitoring of sequential infection in Acinetobacter baumanni and Stenotrophomonas maltophilia is very important for clinic so as to choose antibiotic rationally and improve curative effect