Progression in the study of spinocerebellar ataxia / 第二军医大学学报

ABSTRACT

Loss of cerebellar Purkinje cells,neurons of brain stem and degeneration of spinal ciruits are major morphologic changes in most patients with ataxia.Studies on spinocerebellar ataxia have focused on pathogenesis in recent years. Different genotypes have been identified by genolineage analysis and gene study. This study reviews the literatare on the classification,clinical features and pathogenesis of spinocerebellar ataxia.