Design of livin antisense oligonucleotides with computer / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics
;
(12)2004.
Article
in Chinese
| WPRIM
| ID: wpr-556921
ABSTRACT
AIM:
Antisense oligonucleotides against livin were designed with computer software.METHODS:
Antisense oligonucleotides were designed according to the secondary structure of livin mRNA which was simulated with RNAdraw and Sfold. And then these oligonucleotides were transfected into Hela cells for inducing apoptosis.RESULTS:
Five antisense oligonucleotides were designed using RNAdraw and Sfold, and effectively induced Hela cell apoptosis.CONCLUSION:
The approach is effective and feasible to design antisense oligonucleotides by means of calculation with two kinds of software.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Pharmacology and Therapeutics
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS