The effects of supplemented with DHA on synaptic plasticity during development period in rats / 中国药理学通报

ABSTRACT

Aim To discover the change of synaptic plasticity by supplementing DHA during development period in rats. Method We divided Wistar rats into two groups fish oil group and control group. The fish oil rats were supplemented with fish oil(5?10~3 ml?g-1 body weight) by gavage daily. The control rat was supplemented with NS of the same dose. 90 days later, each rat was hippocampus of anaesthetized and LTP and LTD were recorded at hippocampus of the same rat. Result Compared to the control group, DHA group presented an obvious increase in PS LTP, while no changes were found in EPSP LTP. On the other hand,DHA group demonstrated an obvious canceling effect on both EPSP and PS LTD. Conclusion There exist effects on synaptic plasticity after supplement with DHA. It may be one of the factors that DHA improves learning and memory.