The correlation between recurrence of superficial bladder cancer and histology manifestation or Ki-67, p53 expression / 解放军医学杂志

ABSTRACT

Objective To approach the correlation between histology manifestation or Ki-67, p53 expression and superficial bladder cancer. Methods 54 cases of superficial bladder cancer were classified into two groups(with and without recurrence). The histological morphology was reviewed according to the 1998 WHO/ISUP classification. The expression of both Ki-67 and p53 was detected with immunohistochemical method, and a comparison was made between with- and without recurrence group. Results The average duration of follow-up survey for the patients was 32 months. Among the 54 patients, 28 got recurrence. Of the recurred cases, 5 were papillary urothelial neoplasm of low malignant potential (PUNLMP), 14 were low grade papillary urothelial carcinoma (LGPUC), and 9 were high grade urothelial papillary carcinoma (HGPUC). While among the 26 cases without recurrence, 4 were papilloma, 12 were PUTLMP, 8 were LGPUC, and 2 were HGPUC. The recurrence rate was 29.4% (5/17) in PUTLMP, 63.6% (14/22) and 81.8% (9/11) in LGPUC and HGPUC, respectively. There was a significant difference in Ki-67 and p53 expression between the recurrence and non-recurrence groups, the positive rate in recurrence group was significantly higher than that in non-recurrence group (P