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Surgical left ventricular repair combined with skeletal myoblast transplantation for ischemic congestive heart failure after myocardial infarction / 第二军医大学学报
Academic Journal of Second Military Medical University ; (12)2001.
Article in Chinese | WPRIM | ID: wpr-557299
ABSTRACT

Objective:

To evaluate the therapeutic effect of combined procedure of surgical left ventricular repair (LVR) and skeletal myoblast transplantation for congestive heart failure after myocardial infarction.

Methods:

Forty-eight male adult Lewis rats, with a four-week old myocardial infarction created by left coronary artery ligation, were randomized into 4 groups group Ⅰ (n=10) received phosphate-buffered saline (PBS) injection into the border zone of the infarction; group Ⅱ(n=11) received myoblast injection ; group Ⅲ(n=13) received left ventricular repair and simultaneous PBS injection; and group Ⅳ (n=14) received left ventricular repair and myoblast injection. Echocardiography was performed once a week until the fourth week after the treatment.

Results:

Left ventricle end diastolic diameter (EDD) and end systolic diameter (ESD) declined significantly one week after the LV repair in group Ⅲ and Ⅳ, then increased as time passed; on the fourth week, there were no statistical differences between group Ⅰ,Ⅱ and Ⅲ, but group Ⅳ was still much smaller than the other 3 groups(P

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial Language: Chinese Journal: Academic Journal of Second Military Medical University Year: 2001 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial Language: Chinese Journal: Academic Journal of Second Military Medical University Year: 2001 Type: Article