Clinical studies on the protective effect of propofol in surgery of acute cranial trauma / 解放军医学杂志

ABSTRACT

Objective To investigate the changes in neuron-spe ci fic enolase (NSE) and S100B in patient′s serum before, during and after surgery of acute cerebral trauma, and to examine the influence of propofol, a venous an esthetic, on these changes, so as to evaluate the brain-protective effects of t his agent. Methods Ten patients with no cerebral injury and sch eduled for urological operation served as control group. Thirty patients with ce rebral trauma were randomly allocated to either propofol group (n=15) or iso flurane group (n=15). NSE and S100B were measured by ELISA in both propofol and isoflurane groups before surgery, 2 hours after cranial surgery started, and after surgery. The same measurement was done in the control group only before s urgery. Glasgow scores of patients with cerebral trauma were estimated and recor ded. Results Before surgery, the NSE and S100B in the patients with cerebral trauma were significantly higher than that in the control group ( P