No Association Between the 5-HT 2A Receptor Gene Promoter Polymorphism(-1438A/G) and Schizophrenia in a Korean Population / 신경정신의학
Journal of Korean Neuropsychiatric Association
; : 334-341, 2001.
Article
in Ko
| WPRIM
| ID: wpr-55740
Responsible library:
WPRO
ABSTRACT
OBJECTIVES: This study was designed to investigate the association between 5-HT 2A receptor gene promoter -1438A/G polymorphism and schizophrenia in a Korean population. METHOD: 5-HT 2A receptor gene promoter -1438A/G polymorphism was typed with Polymerase Chain Reaction in 132 patients with schizophrenia and 138 healthy normal controls. RESULT: There was no difference in allelic frequency of -1438A/G polymorphism between patients with schizophrenia and controls(K 2=2.261, df=1, p=0.133). A difference was found in genotype distribution(K 2=6.157, df=2, p=0.046), but this difference was being given by the increased A/A in th controls and A/G in the patients. The genotype frequency, which is the sum of homozygosity and heterozygosity for the -1438 G allele, was significantly higher in the patients(K 2=5.880, df=1, p=0.015). However, there was no difference between the patients with schizophrenia and conrols in the frequency of homozygosity for the -1438 G allele. CONCLULSION: These results suggest that -1438A/G polymorphism of the 5-HT 2A receptor gene promoter is not causally related to the development of schizophrenia in a Korean population.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Schizophrenia
/
Serotonin
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Polymerase Chain Reaction
/
Alleles
/
Genotype
Limits:
Humans
Language:
Ko
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2001
Type:
Article