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Effect of luteolin on ulcerative colitis in mice / 中国临床药理学与治疗学
Chinese Journal of Clinical Pharmacology and Therapeutics ; (12)2004.
Article in Chinese | WPRIM | ID: wpr-557403
ABSTRACT

AIM:

To evaluate the effect of luteolin on ulcerative colitis in experimental animals.

METHODS:

The mouse model of acute colitis was induced by instillation of dinitrochlorobenzene (DNCB) /alcohol. Luteolin (1, 10 and 50 mg?kg~(-1)) were orally administrated to mice for 3 days. Diarrheas, colon weight index, macroscopic damage in the colon were observed and the activity of MPO and the content of PGE_2 in colon were also examined.

RESULTS:

The diarrhea and the colon weight in- dex were reduced and the macroscopic damage in the inflammatory colon was effectively attenuated by luteolin. The elevated level of MPO and PGE2 were also significantly decreased.

CONCLUSION:

Luteolin can effectively inhibit the inflammatory infiltration, bleeding and proliferation in experimental ulcerative colitis.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Clinical Pharmacology and Therapeutics Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Clinical Pharmacology and Therapeutics Year: 2004 Type: Article