Relationship between Glutathione and related enzymes and multidrug resistance / 中国临床药理学与治疗学

ABSTRACT

Multidrug resistance to chemotherapeutic drugs is an important reason for clinical chemotherapy failure. The mechanisms of the classical drug resistance such as P-gp, MRP have been clarified. Hence, it is very important to further study the non-classical mechanism of multidrug resistance. We introduced the effects on MDR, the possible mechanisms of glutathione and related enzymes, as well as the relationship between structure of GSH analogues and the transport activity in this paper.