A preliminary report of the treatment of endometrial cancer with californium-252 neutron intracavitary brachytherapy / 解放军医学杂志

ABSTRACT

Objective To evaluate the treatment of advanced endometrial cancer with californium-252 brachytherapy. Methods 21 cases of endometrial cancers who had not received any treatment were diagnosed as in the stages Ⅰ～Ⅳ according to the criteria of FIGO. Treatment schedule included 252Cf brachytherapy, 8～12Gy/fraction/week, the total dose of reference point A was 35～45 Gy and total dose of reference point F was 35～50Gy in three to four implant sessions. On the second day after 252Cf therapy, the whole pelvis was treated with 6MV X-ray external beam radiotherapy, 200 cGy per fraction, 4 times per week. The total dose of external beam radiotherapy was 45 to 50 Gy (the middle of pelvis was shielded with 4cm of lead), and the total treatment time was 5～6weeks. The recent therapeutic effect and complications were observed. Results The average time of complete tumor regression was 25 days, the local control rate was over 90%; the late radioactive complications of bladder and rectum was low during the 5-year follow-up period. Conclusions Combined californium-252 brachytherapy and high energy X-ray external beam radiotherapy may be safe and effective on advanced endometrial cancer.