Effect of ecdysterone on glucose consumption of HepG2 Cells / 中国药理学通报
Chinese Pharmacological Bulletin
; (12)2003.
Article
in Zh
| WPRIM
| ID: wpr-557591
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WPRO
ABSTRACT
Aim To investigate whether ecdysterone is able to exert glucose-lowering effect on hepatocytes or stimulate the secretion of insulin.Methods For glucose consumption studies,the amounts of glucose disappeared from the culture medium of HepG2 cells within 24 h were determined.?TC3 cells were also used to monitor insulin secretion.Results The glucose concentrations decreased significantly by ecdysterone 1?10~(-6)~10~(-4) mol?L~(-1),while glucose consumption increased by 44%~77% with ecdysterone.Glucose consumption declined as its concentrations increased.Insulin had no effect on glucose-lowering of ecdysterone.?TC3 cells were not stimulated by ecdysterone.Conclusion Ecdysterone is able to exert glucose-lowering effect on hepatocytes which is insulin independent,but has no effect on insulin secretion.
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Language:
Zh
Journal:
Chinese Pharmacological Bulletin
Year:
2003
Type:
Article