Alteration of hydrogen sulfide/cystathionine-?-synthase system in rats with recurrent febrile seizures / 北京大学学报(医学版)
Journal of Peking University(Health Sciences)
;
(6)2003.
Article
in Chinese
| WPRIM
| ID: wpr-557725
ABSTRACT
Objective:
To study the alteration of hydrogen sulfide (H_2S)/ cystathionine-?-synthase (CBS) system during recurrent febrile seizures (FS) in the hippocampus of developing rats.Methods:
The rats were randomly divided into control group (n=8) and hyperthermia-treated group (n=22). Which was subdivided into FS group (n=8) and H group(no seizure occurred, n=9) according to whether seizures occurred. The plasma level of H_2S was detected by the spectrophotometer. The expression levels of CBS gene and protein were examined by in situ hybridization and immunohistochemistry respectively.Results:
The plasma levels of H_2S were increased significantly in FS group compared with those of control group or H group. The expression levels of CBS gene and protein were enhanced in FS group compared with those of control group or H group.Conclusion:
The expression levels of H_2S/ CBS system were up-regulated during recurrent FS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Peking University(Health Sciences)
Year:
2003
Type:
Article
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