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Alteration of hydrogen sulfide/cystathionine-?-synthase system in rats with recurrent febrile seizures / 北京大学学报(医学版)
Journal of Peking University(Health Sciences) ; (6)2003.
Article in Chinese | WPRIM | ID: wpr-557725
ABSTRACT

Objective:

To study the alteration of hydrogen sulfide (H_2S)/ cystathionine-?-synthase (CBS) system during recurrent febrile seizures (FS) in the hippocampus of developing rats.

Methods:

The rats were randomly divided into control group (n=8) and hyperthermia-treated group (n=22). Which was subdivided into FS group (n=8) and H group(no seizure occurred, n=9) according to whether seizures occurred. The plasma level of H_2S was detected by the spectrophotometer. The expression levels of CBS gene and protein were examined by in situ hybridization and immunohistochemistry respectively.

Results:

The plasma levels of H_2S were increased significantly in FS group compared with those of control group or H group. The expression levels of CBS gene and protein were enhanced in FS group compared with those of control group or H group.

Conclusion:

The expression levels of H_2S/ CBS system were up-regulated during recurrent FS.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Peking University(Health Sciences) Year: 2003 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Peking University(Health Sciences) Year: 2003 Type: Article