Galangin (3,5,7-Trihydroxyflavone) Shields Human Keratinocytes from Ultraviolet B-Induced Oxidative Stress
Biomolecules & Therapeutics
;
: 165-173, 2015.
Article
in English
| WPRIM
| ID: wpr-55792
ABSTRACT
Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
DNA
/
Keratinocytes
/
Reactive Oxygen Species
/
Apoptosis
/
Oxidative Stress
/
Phytochemicals
/
Free Radicals
/
Antioxidants
Limits:
Humans
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2015
Type:
Article
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