Correlation of nuclear DNA contents and p53 protein expression with CT image and prognosis of patients with epithelial ovarian tumors / 第二军医大学学报

ABSTRACT

Objective:To observe the nuclear DNA contents and expression of p53 protein in epithelial ovarian tumors(EOT) and to explore their correlation with CT images and prognosis in EOT patients.Methods: The nuclear DNA contents,expression of p53 protein and CT findings of 88 EOT patients were analyzed.Twenty-six EOT patients were followed up and were divided into AT group(aneuploid,n=19) and DT group(diploid,n=7) according to DNA ploid,and into p53 protein(+) group(n=15) and p53 protein(-) group(n=11) according to expression of p53 protein.The correlation of nuclear DNA content and p53 protein expression with CT findings and prognosis of EOT patients was analyzed.Results: The DNA index,patient number with AT and protein p53(+) rate were significantly different between patients with their cystic wall thickness≥3 mm and