Effect of intracoronary carbachol administration on ventricular repolarisation in a sheep model / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1987.
Article
in Chinese
| WPRIM
| ID: wpr-558144
ABSTRACT
Aim To investigate the effect of carbachol on ventricular repolarization in an intact animal heart.Methods In 4 sheep,carbachol was injected to the left circumflex coronary artery(LCX) at 1.0 mol?L~(-1) and 2.5 mol?L~(-1) respectively.Multiple unipolar ECGs were acquired from the epicardium of the LCX territory.Activation-recovery interval(ARI) was analysed from these ECGs.Administration with 2.5 mol?L~(-1) was also repeated after pre-treatment with nitro-L-arginine(20 mg?kg~(-1)),a nitric oxide synthase inhibitor.Results Intracoronary injection with carbachol at 1.0 mol?L~(-1) or 2.5 mol?L~(-1) increased ARI by(38?17) ms and(58?14) ms,respectively(P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1987
Type:
Article
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