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Replication of Caucasian Loci Associated with Osteoporosis-related Traits in East Asians
Journal of Bone Metabolism ; : 233-242, 2016.
Article in English | WPRIM | ID: wpr-55831
ABSTRACT

BACKGROUND:

Most reported genome-wide association studies (GWAS) seeking to identify the loci of osteoporosis-related traits have involved Caucasian populations. We aimed to identify the single nucleotide polymorphisms (SNPs) of osteoporosis-related traits among East Asian populations from the bone mineral density (BMD)-related loci of an earlier GWAS meta-analysis.

METHODS:

A total of 95 SNPs, identified at the discovery stage of the largest GWAS meta-analysis of BMD, were tested to determine associations with osteoporosis-related traits (BMD, osteoporosis, or fracture) in Korean subjects (n=1,269). The identified SNPs of osteoporosis-related traits in Korean subjects were included in the replication analysis using Chinese (n=2,327) and Japanese (n=768) cohorts.

RESULTS:

A total of 17 SNPs were associated with low BMD in Korean subjects. Specifically, 9, 6, 9, and 5 SNPs were associated with the presence of osteoporosis, non-vertebral fractures, vertebral fractures, and any fracture, respectively. Collectively, 35 of the 95 SNPs (36.8%) were associated with one or more osteoporosis-related trait in Korean subjects. Of the 35 SNPs, 19 SNPs (54.3%) were also associated with one or more osteoporosis-related traits in East Asian populations. Twelve SNPs were associated with low BMD in the Chinese and Japanese cohorts. Specifically, 3, 4, and 2 SNPs were associated with the presence of hip fractures, vertebral fractures, and any fracture, respectively.

CONCLUSIONS:

Our results identified the common SNPs of osteoporosis-related traits in both Caucasian and East Asian populations. These SNPs should be further investigated to assess whether they are true genetic markers of osteoporosis.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoporosis / Genetic Markers / Bone Density / Cohort Studies / Polymorphism, Single Nucleotide / Asian People / Genome-Wide Association Study / Hip Fractures Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Humans Language: English Journal: Journal of Bone Metabolism Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoporosis / Genetic Markers / Bone Density / Cohort Studies / Polymorphism, Single Nucleotide / Asian People / Genome-Wide Association Study / Hip Fractures Type of study: Etiology study / Incidence study / Observational study / Risk factors Limits: Humans Language: English Journal: Journal of Bone Metabolism Year: 2016 Type: Article