The pathologic changes of myocardial fibrosis in diabetes mellitus myocardiopathy / 中国实用内科杂志

ABSTRACT

Objective To investigate pathologic changes of myocardial fibrosis at different stages of diabetes mellitus(DM)rats.Methods (1)Cardiac muscle models of DM rats were divided into groups at random.(2)The hydroxy proline contents were measured with the chloramine T method.The type Ⅰ collagen,type Ⅲ collagen,transforming factor beta1(TGF-beta1)and cardiac-type ?-actin were determined by myocardial immunohistochemical stain.(3)Specimen for light microscope and transmission electron microscope preparation.Results The collagen expression of six-month group was much higher than those of three-month group(P