Changes of plasma IL-6 and IL-8 level during anti-endotoxin treatment in patients with obstructive jaundice / 中国基层医药

ABSTRACT

Objective To investigate the changes of plasma IL-6 and IL-8 level and the inhibitory effects of preoperative administraction of bile salt or anti-endotoxin antibody against endotoxin in cases of obstructuve jaundice.Methods 50 cases with obstructive jaundice were randomized into OJT1 group taking bile salt orally,OJT2 group receiving intravenous anti-endotoxin antibody and OJ group receiving general treatment.The plasma levels of endotoxin(ET),interleukin-6(IL-6) and interleukin-8(IL-8) were determined in all the cases.Results The plasma ET level was significantly lower in the patients of OJT1 and OJT2 groups than in those of OJ group preoperatively and was further decreased postoperatively(P