Study on the Antidepressant Effects and Mechanism of Hypericum Perforatum L.(EHP)in Stress-induced Depressive Model / 浙江中医药大学学报

ABSTRACT

[Objective]To study the antidepressant effects and mechanism of Hypericum peratum L.(Elqe).[Methods]Forced-swimming test in mice,tail-suspension test in mice mensurating cerebracontents of monoamine neurotransmitters in chronic stress-induced depressive rats done to study the antidepressant effects and mechanism of extract of Hypericum peratum L [Results]Immobility time of forced-swimming and tail-suspension in mice which were significantly shortened by EHP (320mg/kg,160mg/kg)(P