Studies on the effect of exercises to early steroid-induced femoral head necrosis / 解放军医学杂志

ABSTRACT

Objective To observe the effects of exercises on early stage of steroid-induced necrosis of the femoral head in rabbits with magnetic resonance imaging (MRI). Methods 24 adult rabbits were divided randomly into three groups, i.e. control group (group A), routine model group (group B) and experimental group (group C) with 8 animals for each group. Dexamethasone (DXM) was administrated in a dosage of 2.5mg/kg via intramuscular route to reproduce the aseptic necrosis of femoral head (ANFH) model in groups B and C, while only isotonic physiological saline was given to the animals in group A. MRI examinations were done at 2nd, 4th, 6th and 8th week after administration of DXM for bilateral femoral heads, and also on a medial coronary area of the hip joints with a fixed area of circumambient soft tissure of 3 mm in diameter. Results At 2nd, 4th, 6th and 8th week after the reproduction of the model, the t2-de3d-sag spot-signals given by MRI in the circumambient soft tissue of hip joints were 56.26?0.45, 58.05?0.27, 59.04?0.29 and 59.23?0.25 in group A, 61.40?0.41, 63.71?0.34, 69.65?0.28 and 71.84?0.3 in group B, and 59.54?0.39, 60.06?0.32, 62.71?0.19 and 63.18?0.40 in group C, respectively. Significant differences existed between each of two groups (F=84.93, P