Analysis of gonadotropin-releasing hormone (GnRH) test results in girls with precocious puberty / 소아과
Korean Journal of Pediatrics
;
: 1377-1382, 2009.
Article
in Korean
| WPRIM
| ID: wpr-55857
ABSTRACT
PURPOSE:
The gonadotropin-releasing hormone (GnRH) test results of girls with precocious puberty were analyzed to determine whether this test can efficiently and clearly differentiate between central precocious puberty (CPP) and other disorders.METHODS:
Clinical and laboratory data of 54 girls with precocious pubertal signs were reviewed. Intravenous GnRH test was performed with blood samples obtained at 0, 30, 60, and 90 minutes. A peak luteinizing hormone (LH) level of > or =5.0 IU/L was indicative of CPP.RESULTS:
Of the 40 girls with CPP, 36 (90.0%), 3 (7.5%), and 1 (2.5%) showed peak LH levels at 30, 60, and 90 minutes, respectively. A percentage of girls whose peak LH > or =5.0 IU/L up to 30, 60, and 90 minutes was 92.5%, 100%, and 100%, respectively. The peak LH/follicle stimulating hormone (FSH) ratio of girls with CPP was 0.89+/-0.49 and was 1.0 showed higher chronological age (CA) (8.3+/-0.6 vs. 7.7+/-1.0 years, P=0.033), bone age (BA) (10.9+/-0.8 vs. 9.7+/-1.1 years, P=0.001), and BA-CA difference (2.6+/-0.7 vs. 2.0+/-0.7 years, P=0.009) than those of girls with peak LH/FSH ratio of 1.0 showed advanced breast development (> or =Tanner III) (93.7% vs. 41.7%, P=0.001).CONCLUSION:
LH levels after 30 and 60 minutes of intravenous GnRH administration are the most useful for diagnosing CPP in girls.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Piperazines
/
Puberty, Precocious
/
Breast
/
Luteinizing Hormone
/
Gonadotropin-Releasing Hormone
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2009
Type:
Article
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