Effect of GnRH analogue on the bone mineral density of precocious or early pubertal girls / 소아과
Korean Journal of Pediatrics
;
: 1370-1376, 2009.
Article
in Korean
| WPRIM
| ID: wpr-55858
ABSTRACT
PURPOSE:
Treatment of precocity with gonadotropin releasing hormone analogue (GnRHa) might theoretically exert a detrimental effect on the bone mass during pubertal development. We investigated the short-term changes in bone mineral density (BMD) during GnRHa treatment and the enhancement in the changes with the co-administration of GnRHa and human growth hormone (hGH).METHODS:
Forty girls with precocious or early puberty who were using GnRHa for more than 1 year were enrolled. Of them, 14 concurrently received hGH. Lumbar bone mineral density was measured before and after the treatment, and bone mineral density-standard deviation scores (BMD-SDSs) were compared according to chronologic age (CA) and bone age (BA), as well as according to the administration of GnRHa alone (Group I) or the co-administration of hGH and GnRHa (Group II).RESULTS:
BMDs before and after treatment were in the normal range according to CA but were significantly lower according to BA (P<0.05). During treatment, BMD-SDSs did not change according to CA but significantly increased according to BA (P<0.05). BMD-SDSs in group I did not change during treatment according to CA or BA, while those in group II increased significantly according to BA (P<0.05), but not according to CA.CONCLUSION:
Lumbar BMD was adequate according to CA at initial manifestation of precocity but was lower if compared to BA, that is, BMD did not increase with BA. Because co-treatment with hGH significantly increased BMD-SDSs according to BA, hGH co-treatment could be considered during GnRHa therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Puberty, Precocious
/
Reference Values
/
Bone Density
/
Gonadotropin-Releasing Hormone
/
Puberty
/
Human Growth Hormone
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2009
Type:
Article
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