EFFECTS OF AGAR-OLIGOSACCHARIDES ON BLOOD GLUCOSE LEVEL AND OXIDATION-ANTIOXIDATION STATUS OF DIABETIC MICE / 营养学报
Acta Nutrimenta Sinica
;
(6)1956.
Article
in Chinese
| WPRIM
| ID: wpr-558751
ABSTRACT
Objective:
To evaluate the effect of agar-oliogsaccharides (mainly containing agarobiose) on blood glucose level and oxidation-antioxidation status in alloxan-induced diabetic mice.Method:
The inhibitory activity of agarobiose on ?-glucosidase was investigated. Alloxan was used to establish non-obese diabetic (NOD) mice model. After 14 d administration of agarobiose, blood glucose, MDA, SOD, GSH and GSH-Px levels were determined.Results:
Agarobiose showed inhibitory activity on ?-glucosidase with IC50=1.39 mg/ml, Ki=0.52 mg/ml. In a certain concentration (200-400 mg/kg bw), agaro-oligosaccha- rides reduced the blood glucose level remarkably, and the oxidative indices were also improved in heart, liver, lung and brain. The blood glucose level (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Acta Nutrimenta Sinica
Year:
1956
Type:
Article
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