Subcellular localization of nuclear factor kappa B in term human fetal membranes and myometrium during labor / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 24-30, 2006.
Article
in Korean
| WPRIM
| ID: wpr-55883
ABSTRACT
OBJECTIVE:
To investigate the subcellular localization of nuclear factor kappa B (NF-kappa B) in term human fetal membranes and myometrium during labor.METHODS:
Fetal membranes and myometrial tissue were collected from term pregnant women undergoing cesarean delivery after labor (n=4) and before labor (n=4). An immunostaining was done with NF-kappa B p65 antibody. The intensity and distribution of nuclear immunostaining of NF-kappa B p65 subunit were evaluated visually using a semiquantitative analysis.RESULTS:
NF-kappa B p65 was present in all tissues studied, and it was localized principally in the cytoplasm of cells of amnion and chorion. But, NF-kappa B p65 was localized more abundant in the nucleus than in the cytoplasm in myometrial cells. In amnion, chorion and myometrium, the staining scores of nuclear NF-kappa B did not show any difference between the after-labor group and before-labor group.CONCLUSION:
In human term gestational tissues, subcellular localization of NF-kappa B showed cytoplasmic predominance in amnion and chorion, and nuclear predominance in myometrium. But these subcellular localizations did not change during labor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chorion
/
NF-kappa B
/
Cytoplasm
/
Pregnant Women
/
Transcription Factor RelA
/
Extraembryonic Membranes
/
Amnion
/
Myometrium
Limits:
Animals
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2006
Type:
Article
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