Hypoxia-Inducible Factor-1 and Cerebral Ischemic Tolerance / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-558857
ABSTRACT
Hypoxia inducible factor 1 (HIF-1), a nuclear protein with transcription activity, can make the body produce adaptive response to hypoxia/ischemia by binding to target gene, transcription and post-transcriptional control. Ischemic tolerance refers to the adaptive response to transient ischemia and reperfusion, which can improve tissue tolerance during the following damage caused by more severe ischemic events. The recent studies have found that the expression of HIF-1 has an important significance in ischemic tolerance. HIF-1 may be a key factor of the oxygen signal transduction pathway in the development of cerebral ischemic tolerance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2006
Type:
Article
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