Effect of reversible partial obstruction of common bile duct on function of sphincter of Oddi in dogs / 第三军医大学学报

ABSTRACT

Objective To establish a reversible partial obstruction model of the common bile duct(CBD) in dogs and explore the influence of partial obstruction of CBD on the motility of sphincter of Oddi(SO).Methods Adult mongrel dogs were anesthetized.In the partial obstruction(PO) group,a double ligature was performed around both a cannula(1 mm in diameter) and the common bile duct near to its bifurcation,then the cannula was withdrawn,while in the control group,only sham operation was done.The serum of venous blood was obtained before and on day 1,3,5,7,14,28 after operation.Liver specimens were obtained by biopsy on postoperative day 3,7,14.SO motility was recorded on postoperative day 28.Results All the obsrtuction of CBDs were removed in PO group,the structure of hepatocytes and liver function recovered to normal on day 28 after operation.SO basal pressure(SOBP),SO amplitude(SOAP) and frequency of SO phasic contraction(SOF) significantly decreased,whereas the duration of SO contraction did not change.Conclusion Partial obstruction of CBD inhibited the motility of SO.The clinical manifestation of this model is similar to that of patients with temporary obstructive jaundice that influenced the motility of SO.This model was relatively simple,easy and reliable.