The significance of Inhibition of NF-?B by I?B? in Cerebral Ischemia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-559123
ABSTRACT
Nuclear factor-?B (NF-?B) is a nuclear transcription factor that regulates the expressions of multiple genes. It can be activated during cerebral ischemia; it is closely correlated with the inflammatory reaction and apoptosis during cerebral ischemia. NF-?B inhibitor ? (I?B?), an important inhibitor factor of NF-?B, can regulate the survival and death of neuron in the ischemia penumbra. Therefore, the inhibition of the degradation of I?B? and the prevention of the activation of NF-?B with drugs or molecular biological methods has become an important approach in study of the effect of NF-?B at present. Recent studies have indicated that I?B? itself may also participate in the regulation of apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2006
Type:
Article
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