Effect of combination of extracts of ginseng and ginkgo biloba on neurotransmitters in whole brain of ?-amyloid peptide_(1-40)treated rat / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-559197
ABSTRACT
Aim To detect the effect of a combination of extracts of ginseng and ginkgo biloba(Naoweikang,NWK) on acetylcholine,monoamines and their metabolites in ?-amyloid peptide(A?)_(1-40) treated rats and the potential mechanisms.Methods A 1-month NWK(15.5,31 and 62 mg?kg~(-1),respectively) administration to rats was performed daily after bilateral injection of A?_(1-40)(4 g?L~(-1) for each side) into hippocampus.Acetylcholine(ACh) was determined with an improved HPLC-ECD method,which is combined with two immobilized enzyme reactors.Monoamines and their metabolites were also determined with HPLC-ECD.Result Compared with shams,ACh and serotonin(5-HT) in whole brains in models decreased significantly(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article
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