ROS level and ASK1 protein expression in myocardium during chronic pressure overload in rat left ventricle / 第三军医大学学报
Journal of Third Military Medical University
;
(24)2002.
Article
in Chinese
| WPRIM
| ID: wpr-559336
ABSTRACT
Objective To study the effect of apoptosis signal regulating kinase 1(ASK1) protein expression in hypertrophic myocardium in rat models of hypertension.Methods The rat model of hypertension was established by abdominal aortic constriction.Six weeks later,the reactive oxygen species(ROS) level and ASK1 protein expression in myocardium of left ventricle were detected respectively by color matching and Western blotting.Results The left ventricular mass index,ROS level and ASK1 protein expression all increased significantly in hypertensive rats as compared with those underwent sham operation.Conclusion Under chronic pressure overload,the activated ASK1 with the increasing ROS may play an important role in signal transduction pathway of myocardial hypertrophy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Third Military Medical University
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS