Analyzing physiological factors related to acute mountain sickness with multivariate regression / 第三军医大学学报

ABSTRACT

Objective To analyze the physiological factors related to acute mountain sickness(AMS) and establish a multiple line regression model to predict the AMS.Methods A total of 113 men aged(19?1) years were enrolled in this study.At 300 m above sea level,the pulmonary function by Vmax 229D spirometer,the physiological responses to hypoxia via breathing mixed gas(10% O_(2) and 90% N_(2)) for 10 min,the amount of urine at different time points after fast drinking 1 000 ml water,the responses of breath holding,serum cortisol by RIA,chest volume etc.were investigated.The symptomatic scores of benign form of AMS were calculated on day 2,3 after the subjects arrived at Lhasa(3 658 m above sea level).Multivariate linear regression analysis was used to check out the factors related to AMS.Results The chest volume,forced vital capacity,forced expiratory volume in 1 s,peak expiratory flow(PEF),the amount of urine within 1.5 h,2 h and 2.5 h after fast drinking 1 000 ml water,and the heart rate at 7~(th) min during breathing hypoxic gas were found related to AMS.The model of AMS prediction was as follow scores of AMS=16.108-(0.003 04)?(the amount of urine within 2.5 h after drinking(1 000) ml water)-0.441?PEF-(0.048 7)?(the heart rate at 7~(th) min during breathing hypoxic gas)-0.240?chest volume.Of this equation,F=5.889(P