Recent progress in weight reduction mechanism of inhibitor of fatty acid synthase / 中国药理学通报

ABSTRACT

Fatty acid synthase is the key enzyme which catalyzes the de novo synthesis of long-chain fatty acids from acetyl-CoA and malonyl-CoA.Only recently has it been appreciated that C75,the inhibitor of fatty acid synthase can make mice lose weight via reducing food intake and increasing energy consumption.The present paper reviews the potential mechanism by which the inhibitor of fatty acid synthase may influence the expression of hypothalamic neuropeptides mediating the behaviour of food intake in central nervous system and decrease adipose sediment or increase energy production.