The efficacy and safety of trimebutine maleate in the treatment of functional dyspepsia / 中国基层医药

ABSTRACT

Objective To validate the clinical safety and efficacy of trimebutine maleate in the treatment of functional dyspepsia(FD).Methods 64 patients with FD were recruited into the study and ramdomly divided into two groups,each 32 examples.The observed group was given trimebutine maleate 200mg,po,tid,and the matched group was given oryzanol 10mg po,tid.The treatment circumstance was recorded one day before the treatment,and once a week for two weeks.Results After 2 weeks observation,drug efficacy to the symptom of naupathia,abdominal pain,diarrhoea and constipation were 86.7%,90.4%,84.6% and 85.7%,respectively.The observed group had gross efficiency for 82%,with the machted group for 54.0%.No side effect was observed.Conclusion Trimebutine is an effective agent for treatment of FD,and has no obvious side effect.