An analysis of the clinical features of 424 cases of hepatitis E / 解放军医学杂志

ABSTRACT

171.1?mol/L) was 25.0%, 37.7% and 46.3%, the percentage of the fulminating hepatitis was 3.0%, 5.9% and 14.0%, and the mean hospital stay days for the convalescent patients were 31.59?18.97, 31.13?13.70 and 37.51?18.33 days, respectively. All these variables were significantly higher in aged group compared with youth and middle-aged groups. The levels of alanine transaminase (ALT) lowered significantly with the advance of age, and they were 1 711.7?1 063.4, 1 423.0?913.2 and 1 162.7?792.5U/L, respectively. The same was true in serum albumin and choline esterase (ChE). On the other hand, the percentage of acute hepatitis without jaundice decreased to 17.9%, 6.4%and 2.5% from the youth to the aged. However, TBIL on admission (131.41?106.97 vs 169.60?136.11 vs 164.36?106.22?mol/L) and the elevation of the peak of TBIL (135.01?109.15 vs 186.08?150.64 vs 209.63?143.74?mol/L) of the middle-aged and the aged were significantly higher than those of the youth. There was no significant difference in the symptoms, the ratio of direct to total bilirubin, mortality to complications among them. Furthermore, the serum IgM and IgG antibodies against HEV were negative in about 8.1% of the patients with HEV. Conclusion With a higher incidence and more severe hepatic damage, the middle-aged and the aged patients need a longer duration for recovery than the young patients.